Principal Investigator – Early Phase Clinical Trials

About the role

Join Nucleus Network as a Principal Investigator to lead early‑phase clinical trials, including first‑in‑human studies, at our Brisbane unit. You will work within a multidisciplinary team delivering safe, high‑quality Phase 1 data.

Key responsibilities

• Review clinical trial protocols and investigator brochures in depth.
• Ensure safe and effective implementation of early‑phase trials, monitoring safety and managing adverse events.
• Provide medical services to trial participants and support biotech/pharma partners on protocol design.
• Attend Safety Monitoring Committee meetings and contribute to dose‑escalation decisions.
• Supervise and mentor junior medical officers and offer medical advice across the organisation.

Required profile

• Full Australian work rights and AHPRA registration as a medical practitioner.
• FRACP or fellowship of a relevant specialist college.
• Strong communication skills and ability to work effectively in a team.
• Interest in new drug development; PhD or higher research degree is advantageous but not essential.

Required skills

• Application of ICH Good Clinical Practice and relevant regulatory guidance.

What we offer

• Fitness Passport, Reward Hub discounts, wellbeing initiatives, recognition programs and EAP support.
• Opportunities to work across the full clinical trial lifecycle and develop your career in a global organisation.